EXEM® FOAM 2017-10-23T06:28:33+00:00

ExEm® Foam

ExEm® Foam has been developed for ultrasound assessment of tubal patency. By mixing ExEm® gel and ExEm® water, a gel foam is created. ExEm® Foam can be infused through the cervix and the uterine cavity into the fallopian tubes and thus creating a perfect extension of the walls of the fallopian tubes. Utilizing our specially designed and patented catheter with cervical applicator enables a smooth infusion of the gel foam and better visualization of the contour of the tubes. We are proud today ExEm® Foam is recognized as a unique player in the fertility market, offering gynecologists a tubal patency test at their office using Sonography.

Benefits of ExEm® Foam

  • Office based procedure

  • Superior fill images

  • Used in combination with ultrasound imaging

  • Less need for radiology

  • Simple to use

  • Reduced discomfort for patient

  • Perfect control over administration of gel foam

  • Excellent tubal transit

  • Value for money

Exem foam
Exem foam ultrasound

Courtesy of Dr. C. Exacoustos
Department of Obstetrics and Gynecology, Università degli Studi di Roma, ‘Tor Vergata’, Rome, Italy


ExEm® Foam Kit

ExEm® Foam Kit product and procedure presentation, ultrasound tubal patency test.


ExEm® Foam Kit product and procedure animation.

HyCoSy with ExEm® Foam, a female fertility sonographic examination.
(Spaarne ZKH. Haarlem 03-02-2011)
HyCoSy with ExEm® Foam, a female fertility sonographic examination.
(Spaarne ZKH. Haarlem 15-12-2010)

ExEm® Foam in Summary

ExEm® gel and special designed applicators originally were developed for a more stable filling of the uterine cavity, being a patient and doctors friendly alternative for Saline Infusion Sonography (SIS). [1] Gel Instillation Sonography (GIS) became the first choice diagnostic procedure for uterine anomalies and pathology of the uterine cavity. Hysterosalpingo-Foam Sonography (HyFoSy), using ExEm-gel for creating stable foam, was developed as an office procedure for tubal patency testing. [2,3] The technique was tested in a prospective laparoscopy-controlled study. [4] Hysterosalpingo Contrast Sonography (HyCoSy) is, compared to the Hysterosalpingografy (HSG), a first-line investigation to diagnose female tubal subfertility. [5,6] For tubal patency testing HyFoSy with ExEm® Foam is performing better then HyCoSy with saline in terms of accuracy. [7,8] ExEm-gel is considered to be safe, as the components are well known and have been used intravenously and in the abdominal cavity for other medical purposes. There are no known serious side effects. [9] In a randomised controlled trial HyFoSy turned out to be less painfull than HSG. [10] Furthermore, there are signs that HyFoSy may improve women’s chances of concieving spontaneously, although this has to be investigated in future studies further before firm conclusions can be drawn. [11-12]

GIS and HyFoSy
1. Exalto N, Stappers C, van Raamsdonk LAM, Emanuel MH. Gel instillation sonohysterography: first experience with a new technique. Fertil Steril 2007; 87: 152-155

2. Emanuel MH, Exalto N. Hysterosalpingo-foam sonography (HyFoSy): a new technique to visualize tubal patency. Ultrasound Obstet Gynecol. 2011; 37: 497-499

3. Emanuel MH, van Vliet M, Weber M, Exalto N. First experiences with hysterosalpingo-foam sonography (HyFoSy) for office tubal patency testing. Human Reprod 2012; 27: 114-117

4. Van Schoubroeck D, Van den Bosch T, Meuleman Ch, Tomassetti C, D’Hooghe Th, Timmerman D. The use of a new gel foam for the evaluation of tubal patency. Gynecol Obstet Invest 2013; 75: 152-156 Tubal Patency testing

5. Lim CP, Hasafa Z, Bhattacharya S, Mahesahwari A. Should a hysterosalpingogram be a first-line investigation to diagnose female tubal subfertility in the modern subfertility workup? Human Reprod 2011; 26: 967-971

6. Luciano DE, Exacoustos C, Luciano AA. Contrast Ultrasonography for tubal patency. J Min Inv Gynecol 2014; 21:994-998

7. Rajesh H, Lim SL, Yu SL. Hysterosalpingo-foam sonography: patient selection and perspectives. Int J Womens health. 2016; 9: 23-32

8. Piccioni MG, Riganelli L, Filippi V, Fuggetta E, Colagiovanni V, Imperiale L, Caccetta J, Panici PB, Porpora MG. Sonohysterography: comparison of Foam and Saline. J Clin Ultrasound. 2017; 45: 67-71

Safety and side effects

9. Exalto N, Stassen M, Emanuel MH. Safety aspects and side-effects of ExEm-gel and foam for uterine cavity distension and tubal patency testing. Reprod Biomed Online 2014; 29: 534-540

10. Dreyer K, Out R, Hompes PGA, Mijatovic V. Hysterosalpingo-Foam Sonography (HyFoSy): a less painful procedure for tubal patency testing during fertility work-up compared to (serial) hysterosalpingography. A Randomised Controlled Trial. Fertil Steril 2014; 102: 821-825 Enhanced pregnancy rate?

11. Exacoustos C, Tiberio F, Szabolcs B, Romeo V, Romanini E, Zupi E. Can tubal flushing with Hysterosalpingo-Foam Sonography (HyFoSy) media increase women’s chances of pregnancy? Virtual Poster in: J Min Inv Gynecol. 2015; 22: S238

12. Van Schoubroeck D, Van den Bosch T, Van Tornout K, D’Hooge T, Timmerman D. Spontaneous conception after hysterosalpingo-foam.

ExEm® Foam Kit


an ExEm® Foam Kit presentation will be added soon.

Instructions for Use ExEm

ExEm Foam Kit
Instructions for use in English for 5 ml


Austria Bio-Koreska www.biokoreska.at
Australia Gytech Pty Ltd www.gytech.com.au
Belarus AlenMed www.alenmed.com
Belgium GOODLIFE Pharma SA/NV www.goodlifepharma.com
Benin Burkina Fasso Niger Ghana Ivory coast Togo GOODLIFE Pharma SA/NV www.goodlifepharma.com
Bulgaria Novus www.novus.bg
Cambodia MeetHeng www.meetheng.com
Canada Idoman www.idomansolutions.com
Chili International Medical Products www.impchile.cl
Croatia Medical Intertrade d.o.o. www.medical-intertrade.hr
Czech Republic Pentagen www.pentagen.cz
Denmark NordicCell ApS www.nordiccell.com
Estonia NordicCell ApS www.nordiccell.com
Finland NordicCell ApS www.nordiccell.com
France GOODLIFE Pharma SA/NV www.goodlifepharma.com
Georgia Linori Ltd www.linori.com
Germany DiKaTec Medizintechnik GmbH & Co. www.dikatec-medizintechnik.de
Greece (Cyprus) SuppleKey www.supplekey.gr
Hungary FertiCad www.ferticad.hu
Iceland NordicCell ApS www.nordiccell.com
India DSS Imagetech pvt ltd www.dssimage.com
Ireland de Smit Medical Systems Limited www.desmitmedical.com
Israel Medlife www.medlife.co.il
Italy Cremascoli & Iris Srl www.cremascolieiris.it
Jamaica Harmon Medical Distributors www.harmonmedical.com
Japan IMMC International Medical Management www.imm-c.com
Kenia Pulse Healthcare www.pulsehealthcarekenia.com
Korea WoonamPharm www.woonampharm.co.kr
Kingdom of Saudi Arabia Emirates & World Medical Supplies www.imtma.com
Kuwait Mesca Company W.L.L. www.mescacompany.com
Latvia ViaMedPharma www.viamedpharma.lt
Lebanon IbraHadad www.ibrahadad.com
Lithuania ViaMedPharma www.viamedpharma.lt
Malaysia Othman Wellchem www.wellchem.com
Mauritius Afri Pharma Intl www.afripharma-intl.com
Netherlands Goodlife Fertility B.V. www.goodlife-healthcare.nl
New Zealand REM Systems Ltd www.remsystems.co.nz
Norway NordicCell ApS www.nordiccell.com
Oman Emirates & World Medical Supplies www.imtma.com
Paraguay PROGYNEC S.A. www.progynec.com
Phillipines i-Care Biotechnology Inc www.katoreprobiotechcenter.com
Poland Rovers Polska Sp. z o.o. www.rovers.pl
Portugal SPECULUM Artigos Médicos Lda. www.speculum.pt
Qatar Emirates & World Medical Supplies www.imtma.com
Romania Pondera Medical (Mediq) www.ponderamedical.ro
Serbia Sineks Medical www.sineksmedical.com
Singapore Neuvital Pte Ltd www.neuvital.com
Slovakia Pentagen www.pentagen.cz
Slovenia Medip d.o.o. www.medip.si
South Africa Medi Challenge www.medichallenge.co.za
Spain Dibimed www.kitazato-dibimed.com
Sweden NordicCell ApS www.nordiccell.com
Switzerland HYGIS SA www.hygis.ch
Taiwan Everclear Technology Inc www.evercleartech.com
Thailand MeetHeng www.meetheng.com
Turkey  (Cyprus) Seres Medical www.seresmed.com.tr
UAE Emirates & World Medical Supplies www.imtma.com
UK (incl. Ireland) de Smit Medical Systems Limited www.desmitmedical.com
VietNam Asso Pharma www.assopharma.com